PRINCIPAL INVESTIGATOR

Lidia Vasilieva

Lidia received a BSc degree from Krasnoyarsk State University in Russia and a master's degree from the Institute of Protein Research in Moscow. She then moved to Finland to work with Leevi Kääriäinen on the replication of RNA viruses for her PhD. Her postdoctoral studies led her to Harvard Medical School with a fellowship from the Leukemia and Lymphoma Society. She studied there mechanisms involved in regulation of non-coding transcription in Steve Buratowski’s lab. In 2009, Lidia obtained a Wellcome Trust Career Development Fellowship and started her own research group at the Department of Biochemistry in Oxford.

POSTDOCTORAL FELLOWS

Adrien Birot

Adrien joined our lab after completing his PhD with Jean-Paul Javerzat at IBGC, Bordeaux, France, where he studied regulation of cohesin by phosphorylation. Adrien would like to understand how the nuclear exosome is targeted to specific mRNAs by identifying novel exosome cofactors using proteomic and genetic approaches. In a complementary approach, Adrien uses smFISH to understand the interplay between mRNA export, nuclear retention and decay.

Krzysztof Kuś

Krzysztof obtained his PhD with Alekos Athanasiadis at Instituto Gulbenkian de Ciência, Portugal in structural virology. Krzysztof undertakes structural approaches to understand how RNA-processing factors interact with RNA polymerase II.

GRADUATE STUDENTS

Ava Chan

Ava obtained her BSc in Hong-Kong. She joined our lab as a MSc student. Ava would like to understand the role of CID-RRM factors in transcription and mRNA 3’end formation.

Katie Oberheim 

Katie joined our lab after completing her MSc at King's Collage London. She is originally from Birmingham. Katie is interested in understanding mechanisms involved in targeting nuclear exosome to the RNA substrates using biochemical approach.

Emily Priest

Emily completed her BSc at the University of York. Emily studies function of the co-factors to uncover molecular mechanisms underpinning their function in targeting nuclear exosome to mRNAs using biochemical approach. She also collaborates with Adrien to understand further mechanistic links between mRNA decay and export.   

FORMER LAB MEMBERS

Dong-hyuk Heo

Dong-Hyuk did his PhD at Korea University in Seoul, South Korea with Cheol-won Yun. Dong-hyuk would like to understand molecular mechanisms involved in coordinating transcription and RNA regulation.

Takuya Kajitani

Takuya visited our lab for several months and had contributed to a project focused on understanding role of RNA polymerase II pausing in transcriptional regulation. He has obtained a fellowship to continue his research in Japan.

Dogukan Ulgen 

Dogukan obtained his MSc in Ankara, Turkey. In our lab he studies function of proteins that interact with mRNA 5’end CAP structure (S. pombe CBC1 and 2, homologues to human CBP80 and 20) in RNA regulation. 

Tea Kecman

Tea has been a PhD student in our lab. Tea’s work has contributed to understanding how RNA polymerase II transitions from elongation to termination stage of transcription. She has now taken up a position as senior research scientist at University associated company in Netherland

Cornelia Kilchert

Cornelia Kilchert joined our lab as a SNF and DFG postdoctoral fellow. Cornelia discovered a connection between efficiency of mRNA-processing (splicing) and targeting of nuclear exosome. She demonstrated that this mechanism regulates levels of specific transcripts to mediate survival during DNA damage. Cornelia has now established her own research group in Gießen, Germany funded by Emmy-Noether programme.

Sina Wittmann

Sina was a PhD student in our lab. Sina’s work shed light on the mechanisms involved in mRNA 3’end processing and termination of RNA polymerase II transcription. She is now a postdoctoral fellow at Tony Hyman’s lab at Max Planck, Germany funded by EMBO long-term fellowship.

 Beth Watts

Beth was working on the project focused on understanding role of chromatin modifications and transcription factors in supressing unwanted cryptic transcription. She is now a chemistry teacher in St. Edwards school in Oxford.

 Sneha Shah

Sneha was a PhD student. Her work uncovered role for non-coding transcription in regulating expression of adjacent protein-coding in response environmental stimuli. She subsequently went to do a postdoc at Harvard, Boston, USA supported by the Wellcome Trust/DBT India Alliance Postdoctoral Fellowship.

Adam Volanakis

Adam was a MSc student in the lab. His work in our lab had revealed unexpected
role of mRNA splicing in negatively regulating mRNA levels. Adam completed Wellcome Trust funded PhD in Oxford with Nick Proudfoot and is now a postdoc at Harvard funded by Long term EMBO fellowship.

Sarah Coy

Following a postdoc in our lab Sarah took a job as a program manager at Nuffield Department of Population Health. Sarah was interested to understand how some transcripts such as stable non-coding RNAs involved in splicing and rRNA processing (sn/snoRNAs) are trimmed rather than degraded by the nuclear RNA exosome. She identified a mechanism involved in stabilisation of the processed ncRNAs producing functional mature sn/snoRNAs. 

Monica Passoni

Monica did a short postdoc in our lab. She collaborated with Adam on project investigating mechanism of spliceosome-mediated-decay and they shared first co-authorship in Genes and Development paper. She is now dedicated to her family raising her children.

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